Cialis Professional as Qualified ED Treatment

Cialis Professional is one of the most-selling medications in the world. It helps fast and effectively struggle erectile dysfunction – one of the most widespread man diseases, especially in men over 45. For many, buying Cialis Professional would be the optimal thing to deal with their sexual problems thanks to the simplicity, speed, and effectiveness. However, it is always recommended to address to a doctor before taking Cialis in order to find out whether this drug suits you or not. Cialis Professional has the same action and manifestations as the original Cialis. The Professional form is costs very cheap for the reasons we already know. Generic and original versions have Tadalafil substance in the same quantities and type. Buying cheaper generic drug will not make you lose, as you receive a high-quality and effective medication not paying someone for the commercial, brand name, and other side expenses. That makes you spend on the treatment of your problem much lesser costs.

Who is predisposed to the erectile dysfunction?

Erectile dysfunction can be distressing and lead to relationship difficulties, anxiety, and depression. Your regular doctor may recommend counselling. This may help resolve the cause of erectile dysfunction. In some cases a problem of performance anxiety can be overcome by breaking the cycle of failure with tablet treatments. For example, this disease occurs in:

• about 12 % of men younger than 60
• 22 % of men age 60 to 69
• 30 % of men age 70 or older

Sexual stimulation is required for tablets to work. Without it tablets will have no effect.

How does it work?

It is best to start with a lower strength tablet and build up as needed. One type of tablet sometimes works better than another. You may like to try out different tablets to see which ones suit you best.

Buy Cialis Professional 40mg

One of the main benefits of Cialis Professional is the heightened sensitivity to the penis. This means that it should take less stimulation to achieve an erection for those individuals suffering from erectile dysfunction, though stimulation must still be present. It is an over-the-counter medicine approved by the Food and Drug Administration, making it a highly reliable medicine. One more plus, are satisfied customer reviews:

Customers note that the absorption is normal, taste is quite tolerable. The action of Cialis is just perfect. The effect lasts mostly 48 hours. Also, customers advise not to abuse alcohol when taking this drug, a hangover and headache are stronger than usual. During the repeated usage of it without alcohol, the headaches were not observed.

Cialis Professional Precautions

Absorption

Tadalafil is readily absorbed after oral administration and the mean maximum observed plasma concentration (C_max) is achieved at a median time of 2 hours after dosing. Absolute bioavailability of tadalafil following oral dosing has not been determined.

The rate and extent of absorption of tadalafil are not influenced by food, thus CIALIS may be taken with or without food. The time of dosing (morning versus evening) had no clinically relevant effects on the rate and extent of absorption.

Distribution

The mean volume of distribution is approximately 63 l, indicating that tadalafil is distributed into tissues. At therapeutic concentrations, 94% of tadalafil in plasma is bound to proteins. Protein binding is not affected by impaired renal function.

Less than 0.0005% of the administered dose appeared in the semen of healthy subjects.

Biotransformation

Tadalafil is predominantly metabolised by the cytochrome P450 (CYP) 3A4 isoform. The major circulating metabolite is the methylcatechol glucuronide. This metabolite is at least 13,000-fold less potent than tadalafil for PDE5. Consequently, it is not expected to be clinically active at observed metabolite concentrations.

Elimination

The mean oral clearance for tadalafil is 2.5 l/h and the mean half-life is 17.5 hours in healthy subjects.

Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).

Linearity/Non-Linearity

Tadalafil pharmacokinetics in healthy subjects are linear with respect to time and dose. Over a dose range of 2.5 to 20 mg, exposure (AUC) increases proportionally with dose. Steady-state plasma concentrations are attained within 5 days of once daily dosing.

Pharmacokinetics determined with a population approach in patients with erectile dysfunction are similar to pharmacokinetics in subjects without erectile dysfunction.

Special Populations

Elderly

Healthy elderly subjects (65 years or over) had a lower oral clearance of tadalafil, resulting in 25% higher exposure (AUC) relative to healthy subjects aged 19 to 45 years. This effect of age is not clinically significant and does not warrant a dose adjustment.

Renal Insufficiency

In clinical pharmacology studies using single dose tadalafil (5 to 20mg), tadalafil exposure (AUC) approximately doubled in subjects with mild (creatinine clearance 51 to 80 ml/min) or moderate (creatinine clearance 31 to 50 ml/min) renal impairment and in subjects with end-stage renal disease on dialysis. In haemodialysis patients, C_max was 41% higher than that observed in healthy subjects. Haemodialysis contributes negligibly to tadalafil elimination.

Hepatic Insufficiency

Tadalafil exposure (AUC) in subjects with mild and moderate hepatic impairment (Child-Pugh class A and B) is comparable to exposure in healthy subjects when a dose of 10 mg is administered. There is limited clinical data on the safety of CIALIS in patients with severe hepatic insufficiency (Child-Pugh class C). If CIALIS is prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. There are no available data about the administration of once-a-day dosing of tadalafil to patients with hepatic impairment. If CIALIS is prescribed once-a-day, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. There are no available data about the administration of doses higher than 10 mg of tadalafil to patients with hepatic impairment.

Patients with Diabetes

Tadalafil exposure (AUC) in patients with diabetes was approximately 19% lower than the AUC value for healthy subjects. This difference in exposure does not warrant a dose adjustment.

Taking Cialis Professional

Improving lifestyle factors such as diet, exercise, smoking, excessive alcohol, and maintaining an active lifestyle has shown improvement in ED in men of all ages. Apart from the general benefits of a healthy lifestyle, studies show improvement in erectile dysfunction symptoms and a reduced need for tablets. ED also shares risk factors with a range of other medical conditions including diabetes, heart disease, and circulatory problems, all of which are also likely to benefit from lifestyle modification.