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Erectile dysfunction: Cialis and other oral medications

ED increases with age, effecting up to 50% of men by the age of 45. In many men there is no significant psychological cause. In other men stress, relationship difficulties, and psychosexual factors play a role and for these men counselling may be preferable. Sometimes a combination of oral medications and counselling works best.

The most important component of diagnosing erectile dysfunction is obtaining a complete medical and sexual history. It is important to distinguish the condition from other sexual dysfunctions, such as premature ejaculation and loss of libido.

The erectile dysfunction drugs market is categorized on the basis of mode of administration into oral medications, topical medications, injections, and others. The oral medication segment is likely to dominate the market since the first line of treatment or medication for erectile dysfunction comprises of oral medication.

Oral medications are often the first line of treatment for erectile dysfunction. For most men who have trouble keeping an erection, these medications work well and cause few side effects. Tadalafil (Cialis) and vardenafil (Levitra), are the most popular oral medications, after Sildenafil (Viagra), that reverse erectile dysfunction by enhancing the effects of nitric oxide, a natural chemical your body produces that relaxes muscles in the penis. This increases blood flow and allows you to get an erection in response to sexual stimulation.

The industry participants in USA considerably spend more on R&D activities and also the region has high healthcare investments and government funding. Development in the emerging areas like orphan drugs and biosimilars is likely to promote the demand for regulatory expertise thereby contributing to the growth of erectile dysfunction drugs market in this region. Besides, sedentary lifestyle, hypertension, stress, anxiety, and chronic diseases are other factors responsible for the growth of the market in USA.

The circumstances surrounding erectile dysfunction may be helpful in determining whether a situational or nonorganic factor is involved. Sudden onset, maintenance of nocturnal erections, presence of psychological problems and concurrent major life events or relationship issues may be associated with nonorganic erectile dysfunction. Concurrent medical illnesses and any medications the patient may be taking should be reviewed. Erectile dysfunction is often a component of generalized medical illness and may represent the initial presentation of cardiovascular disease or diabetes. The history may also reveal certain reversible or modifiable risk factors, such as tobacco use or inadequate diabetes control.

What are the causes of erectile dysfunction?

A diagnosis of erectile dysfunction is made when a man has a consistent or recurrent inability to either obtain or maintain an erection allowing for completion of sexual activity.6 Usually the diagnosis of erectile dysfunction should be made after at least 3 months of symptoms; however, if some type of trauma occurred prior to the patient developing symptoms, the patient may be diagnosed with erectile dysfunction in a shorter time frame. Patients can be diagnosed according to self-reported symptoms or by physiologic testing. If necessary, partner reporting may be used to initiate the process of screening a patient for erectile dysfunction. Several diseases, including cardiovascular disease, may cause or worsen erectile dysfunction. Unfortunately, many medications, including those used to treat cardiovascular disease, may also cause or worsen the problem. In addition to physiologic causes, psychologic causes such as anxiety or relationship issues, may lead to erectile dysfunction.

Erectile dysfunction may be classified as organic, psychogenic, or a mixture of both. Organic includes erectile dysfunction caused by neurologic factors, penile structure, vascular abnormalities, or medications. Psychogenic erectile dysfunction may be associated with several factors, but is frequently linked to performance anxiety, lack of libido, or other psychiatric conditions, such as depression. In purely psychogenic erectile dysfunction, the patient will report that they are able to obtain an erection at times not related to sexual activity but not during periods of sexual stimulation. Neurologic diseases, such as Parkinson's disease or Alzheimer's disease, may also lead to erectile dysfunction by decreasing the patient's libido or by inhibiting the signaling to start an erection. Advancing age may lead to both a decrease in testosterone levels and a change in the vasculature of the penis. Finally, the risk of erectile dysfunction increases with increasing number of medications being taken, especially blood pressure-lowering medication. Other medications, such as selective serotonin reuptake inhibitors, decrease libido in some patients, which may lead to erectile dysfunction.

ED treatment options

Treatments for ED usually can be classified into several categories. Medications – The most common treatment for ED are the oral prescription medications. They work by bringing more blood to the penis to improve the rigidity of erections. Most people are candidates but care should be taken with some medications and cannot be taken with nitrates.

Vacuum erection devices (VED) – These devices work by using negative pressure to the penis and keeping in the penis with an elastic tension ring. VEDs can help most people but can be uncomfortable.

Injectable Medication and Intraurethral Suppositories – The next line of treatments work by placing medications directly into the penis through an injectable or intraurethral suppository. Self-injections work by injecting medication directly into the corporal bodies to induce an erection. Injections work well for most people but the man or his partner must be willing to inject the medication into the penis.

Prosthesis – For those men who wish to achieve an erection but have failed the previous treatments, a penile prosthesis is the final option. Penile implants typically consist of inflatable cylinders that are placed into the corporal bodies of the penis in the operating room. Patient satisfaction is high with penile prostheses and can be a life-changing event for many men.

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Let's take a closer look at the most common treatment for ED — the oral prescription medications.

How oral ED medications differ

Although they work in similar ways, each oral medication has a slightly different chemical makeup. These minor differences affect the way each medication works, such as how quickly it takes effect and wears off, and the potential side effects. Your doctor will consider these factors as well as other conditions you have and possible interactions with other medications you take.

Tadalafil (Cialis)

Cialis (tadalafil) tablets to treat erectile dysfunction available to buy online in daily 2.5mg or 5mg strengths, and as required 10mg or 20mg strengths. Cialis lost its exclusive patent in the USA and is now available legally in the USA under the name tadalafil. Tadalafil is also known as generic Cialis or generic tadalafil. Cialis is a brand name, tadalafil is the medical name.

Cialis from Brand pharmaceutical company is sometimes known as The Weekend Pill. It has been licensed in the USA for over a decade. It was the second erectile dysfunction (ED) prescription medication of its type to receive a USA license, after Viagra (sildenafil). Its prolonged duration of action and the option to take a low dose daily tablet have led to Cialis becoming increasingly popular and being more widely prescribed.

Cialis (tadalafil) and Viagra (sildenafil) belong to a drug class called PDE5 inhibitors, and are used to treat impotence (erectile dysfunction, ED) and enlarged prostate (BPH). Cialis lasts longer in the body than Viagra (about 18 hours compared to 4-6) so it can provide the ability to get and sustain an erection longer. Cialis, along with the other commonly used ED medicines are usually effective and well tolerated treatments. Most men are able to take them and they usually work well. However, men taking some prescription medicines, most notably drugs called nitrates used to treat heart disease, but also some other prescription medicines, should not take Cialis. Men who have some medical conditions, particularly those effecting exercise tolerance should also not take Cialis. Always consult doctor before starting treatment.

If you have never used Cialis before, you may wish to allow an hour for it to work - just to be on the safe side. After the first time, you will know how quickly it works for you. If you find that the dosage is too strong or too weak, you can adjust the dosage the next time you use Cialis. Make sure you do not exceed the maximum recommended dosage of 20mg, as this could result in side effects.

Most men take Cialis occasionally up to a maximum of 2 or 3 tablets per week. They take a tablet if they expect to be sexually active in the following 36 hours. Men who regularly require Cialis more than twice a week sometimes prefer to take a lower dose 2.5mg or 5mg tablet each day, at the same time of day. These low dose tablets are specifically for daily use and provide a continuous level of treatment.

Whether Cialis is the right medication for you depends on your general health, medical history and whether you are currently being treated for other conditions.

Vardenafil (Levitra)

This medication also is most effective when taken one hour before sex and can be taken with or without food. This is the second oral product approved for the treatment of erectile dysfunction. A high-fat meal might keep it from absorbing as quickly. Vardenafil is effective for four to five hours or more if you have mild to moderate erectile dysfunction. A newer form of the drug that dissolves on the tongue might work faster than the pill that you swallow.

Like Viagra, Levitra contains an ingredient called a PDE5 inhibitor. Vardenafil works by loosening blood vessels, easing blood flow to the penis. Does this mean that Levitra and Viagra are effectively the same drug? Not quite. Some men may notice differences in the way these medicines work, and be more suited to one than another. This can make settling on the right medication for erectile dysfunction tricky, particularly for men seeking treatment for the first time. Some may turn to the internet to read Levitra reviews from men who have used it before, to find out more about how well it works, and whether it is likely to cause side effects. Reviews can be a useful tool in helping us to get an idea of what to expect from a product before we buy it. However, when reading reviews online for Levitra, or any medicine for that matter, there are some important factors to take into account. The most critical among these is that reading medicine reviews online should never be considered a substitute for discussing a medicine with your doctor.

The recommended dose is 10 mg taken 1 hour before sexual activity. A higher dose of 20 mg is available for patients whose response to the 10 mg dose is not adequate. Two lower doses (2.5 mg and 5.0 mg) are also available and may be necessary for patients taking other medicines or having medical conditions that may decrease the body's ability to metabolize vardenafil (Levitra). Levitra should not be used more than once a day.

Before taking Levitra, patients are advised to undergo a thorough medical history and physical examination to diagnose the underlying cause of the erectile dysfunction and to identify appropriate treatment.

Sildenafil (Viagra)

This medication is most effective when taken on an empty stomach one hour before sex. It's effective for four to five hours or more if you have mild to moderate erectile dysfunction. Sildenafil is the most effective treatment for erectile dysfunction, but it also has a higher rate of side effects than other options. Men concerned about possible side effects of Sildenafil like headaches, flushing, indigestion and nasal congestion may want to start on Cialis. A 50 or 100 (mg) dose of Sildenafil are the most effective treatment. Smaller doses are less effective. Sildenafil has been studied for more than 15 years in more than 140 completed and ongoing clinical trials involving more than 25,000 men with ED. Sildenafil has an established efficacy and safety profile and remains an important treatment option for men with erectile dysfunction.

Avanafil (Stendra)

Avanafil is a medication that was recently approved by the US Food and Drug Administration for the management of erectile dysfunction. Avanafil is a new phosphodiesterase type 5 inhibitor similar to sildenafil and tadalafil. Patients should take the medication as needed to achieve an erection and should be prescribed the lowest effective dose. The medication was approved on the basis of three trials that showed a benefit over placebo. Avanafil is dosed as 50 mg, 100 mg, or 200 mg tablets. This medication is taken with or without food 30 minutes before sex, depending on the dose. It lasts up to six hours. Stendra (avanafil) is an effective, first-choice treatment for erectile dysfunction, but it can be expensive.

Stendra offers a range of advantages over older medications, ranging from its lower risk of causing side effects to its quicker absorption into the body. One of the biggest advantages of Stendra is that it works quickly, often in as little as 15 minutes after consumption. This makes Stendra the fastest-acting erectile dysfunction treatment currently on the market. If you're looking for a pill that works quickly - meaning you can take it right before sex - Stendra is usually the best choice. Stendra has a slightly longer half-life than Viagra, meaning one tablet it will provide relief from erectile dysfunction for longer than an equivalent dose of Viagra. Avanafil, the active ingredient in Stendra, has a terminal half-life of approximately five hours, meaning it takes five hours to reach 50 percent of its previous concentration in the body. A typical dose of the medication provides relief from erectile dysfunction for around six hours. Like with other ED treatments, it's normal for Stendra to become less effective as more time passes since you took the medication. Because of this, it's best to use the medication shortly before you plan to have sex. In short, you should notice the normal effects of Stendra for about six hours after you take the medication.

Are this oral medications safe?

Before taking any medication for erectile dysfunction, get your doctor's OK. Medications for erectile dysfunction might not work or might be dangerous. Because these drugs are similarly effective, the choice can be based on your preferences, including cost, ease of use, how long the drug's effects last and side effects. There are generic versions of sildenafil, verdenafil and tadalafil available.

Determining the potential benefits

Determining the potential erectile dysfunction oral medications benefits, is much more complex than for drugs that are used to treat cancer, heart disease, or high blood pressure, for example, where one of the potential benefits may be increased survival or avoidance of a heart attack or stroke. It is unlikely that untreated ED contributes to decreased survival, even though it may contribute to emotional distress and strained relationships. Weighing the potential benefits of these drugs involves the interactions in a private relationship based on human emotions and a couple's perception of their quality of life.

There will be many men without erectile dysfunction who will want to try these drugs, seeking to increase their sexual performance. This can only be regarded as risky behavior. Countries like India are the most attractive markets due to the advantages these countries pose like the availability of government support to develop novel drugs thus attracting more number of manufacturers to invest in this region. Besides this, flourishing generic drugs industry, social stigma, growing base of geriatric population, availability of effective treatment methods, high unmet clinical needs, rising disposable income are also some of the other factors accounting for the fastest growth of this region.

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